In the main bag I have organized my clothes in the main compartment into categories, all sealed in 2 gallon ziploc bags. I have 5 shirts, 2 pairs of shorts, 1 pair of swim trunks (plus the pants I will wear on the plane), 5 pairs of socks and underwear, 2 rolls of toilet paper, and a heavy duty rain poncho. In the rest of the bag I have a pair of aqua socks, my steel Spider-Man water bottle (important!), disposable razors, various toiletries (toothbrush, deodorant, etc), a scarf, lonely planet guidebook, leather journal, first aid kit, and passport and necessary papers.
In the smaller bag I have various malaria meds, iodine tablets, mini LED flashlights, some cards for when we get bored on trains and planes, numerous pens and pencils, various small toys to give to local children out there, a lighter, and sunglasses.